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How you could cut your CBD budget

How you could cut your CBD budget
By CBDossier • Issue #5 • View online
Before we dive into discussing CBD tolerance (or the lack thereof), I wanted to share with you a conversation I had with Ashley Alt for her mindset health newsletter Take A Sip. She asked me about launching CBDossier and what I hope you, the audience, will gain from it. As always, I’d love it if you wanted to share your thoughts with me. (You can also just reply to this email.)
Now, on to the last part of the Q&A with Bonni Goldstein, Medical Director of Canna-Centers and author of “Cannabis Is Medicine,” in which we answer some of your questions about feeling nothing when taking CBD and whether we can develop a tolerance to it. In case you missed the first two chapters, read up on CBD dosing here and side effects and interactions with other drugs here.
Question: Is it possible to feel nothing after taking CBD? 
Bonni Goldstein: The vast majority of people who say they tried CBD and it didn’t work for them are underdosing. With CBD, if you find you’re not responding to 20 milligrams a day, it doesn’t mean it didn’t work. It probably means you didn’t take enough. 
There are some people who don’t respond to CBD at all, that definitely exists. And the question is: ‘Why? Maybe they don’t absorb enough?’ We still need a lot more research.
Can we develop a CBD tolerance? And do we therefore need to consider increasing our dose to get the same effect?
We know for sure that THC causes tolerance. If our cannabinoid receptors are being hit by THC on a fairly regular basis and in higher doses, they recognize that too much THC is coming at them and they will migrate inside the cell and are unavailable to interact with THC. That’s the concept of tolerance: You need more to get the same benefit because the overall number of targets is down. When you stop using THC, over time those receptors will migrate out again to be available.
CBD doesn’t bind to the receptors like THC does, so it doesn’t cause tolerance. I have patients who are using the same dose of CBD over time without having to increase the dose. 
There is something called reverse tolerance, which means that you eventually don’t need as much medicine. We think that’s because you went from an unbalanced to a more balanced state, by taking CBD over some time, and then you just don’t need as much to keep the wheels rolling. This is not proven, but we have an idea that maybe this is what’s happening. 
I have patients who come to me in dire straits. They come up with their cannabis regimen, and then all of a sudden, they’re doing great, and they feel like they don’t need as much. Why? The ECS that couldn’t catch up by itself got back into balance with the help of cannabis. It doesn’t work like that for everybody, but a lot of my patients find a very nice balance where they just don’t need as much. 
Would you encourage users to test out if taking less CBD works just as well? Since CBD is not exactly cheap, it could save them some money. 
Absolutely. I have patients who can go several days without their CBD and they’re okay, because the inflammation doesn’t just pop right back up. Someone with epilepsy likely has to take it every day because they need to have a steady state. But someone with pain, anxiety and other conditions that come and go, may find that they can try different doses, timing and products to see what works best for their particular situation. 
Should you experiment? Sure, take a day off, see how you feel. You may find that you can get away with every two- or three-days dosing. That’s how people find out what their personal regimen is.
But just the same way you may feel you don’t need as much, what if you lose your job, you’re having trouble paying your bills and your anxiety is sky high? You may find you need more as life happens. I find cannabis a very flexible medicine that most people can customize to suit their needs.
📧 What experience do you have with taking CBD?
Tell us your story by contributing to CBDiaries. (You’ll find the latest at the bottom of the newsletter.) Any other questions, thoughts, feelings? Please send them to me.

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With the goal of sharing authentic experiences and bridging knowledge gaps, CBDiaries collect personal accounts from readers. If you’d like to contribute, please fill out this form.
CBDiary #5: Roman, 36, Andalusia, Spain
I first became interested in CBD: In 2018, to help out with anxiety and instead of taking pharmaceutical drugs. I was going through a post-startup burnout and a psychiatrist wanted to put me on pharmaceutical meds. At the same time, I worked with a medical cannabis company and read a lot of publications, research, etc. about medical cannabis and which conditions it can be used for. 
How I could tell that it worked for me: When I moved from a low daily dose (10 milligrams per intake) to a higher dose (50 milligrams per intake once a day). I took CBD for around 18 months and it totally helped. Thanks to it I started to have days without worrying about everything obsessively and to just be present and enjoy the day. I became less tense, less irritable, and both my body and mind became more relaxed. 
What would you like to know about CBD? I would like to see more research in a medical context. It is a nicely marketable product in the wellness sector, but in my opinion that image is more damaging to CBD than if it was a regulated medical product. 
My preferred form of taking CBD: Capsules (10, 30 and 50 milligrams).
Side effects: Sometimes I felt like I was being too relaxed. Well, it was not a bad thing. I just had days when I took like 70 milligrams (when my perfect dose was 50 milligrams), which made me very chilled-out. I didn’t want to work but do things that I enjoyed, like cooking a nice meal, surfing, hiking, going into nature. Basically, it was making me ultra-present, and because I hadn’t experienced that since probably my teens or twenties, it felt wrong or weird. I felt that I needed to be professionally productive, but I rather wanted to do things that I love.
Thank you for contributing, Roman.
Before You Move On
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CBDossier is written by me, Kim Bode, a business reporter turned product and engagement strategist. I’m deeply committed to independent journalism and seeking out accurate, unbiased information about CBD that is relevant to you. Let me know what interests you.
Big thanks to Meredith Hattam for the CBDossier logo and design as well as The Cartoon Crowd for the illustration.
Thank you for reading.
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